Phosphoinositide 3-kinase-dependent activation of Rac

PDGF stimulates an increase in GTP–Rac via activation of phosphoinositide 3-kinase

BACKGROUND Phosphoinositide 3-kinases (PI 3-kinases) are thought to play an important role in coordinating the responses elicited by a variety of growth factors, oncogene products and inflammatory stimuli. These responses include activation of membrane ruffling, chemotaxis, glucose transport, superoxide production, neurite outgrowth and pp70 S6 kinase. Some of these responses are also known to ...

Phosphoinositide 3-kinase activation and platelet function.

Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B.

The protein kinase B (PKB)/Akt family of serine kinases is rapidly activated following agonist-induced stimulation of phosphoinositide 3-kinase (PI3K). To probe the molecular events important for the activation process, we employed two distinct models of posttranslational inducible activation and membrane recruitment. PKB induction requires phosphorylation of two critical residues, threonine 30...

berberine induced apoptosis of human osteosarcoma cells by inhibiting phosphoinositide 3 kinase/protein kinase b (pi3k/akt) signal pathway activation

background: osteosarcoma is a malignant tumor with high mortality but effective therapy has not yet been developed. berberine, an isoquinoline alkaloid component in several chinese herbs including huanglian, has been shown to induce growth inhibition and the apoptosis of certain cancer cells. the aim of this study was to determine the role of berberine on human osteosarcoma cell lines u2os and ...

Activation of Phosphoinositide 3-Kinase γ by Ras

domain-containing adaptor subunit, p85 , p85 , or p55 , Background: Type I phosphoinositide 3-kinases are rederived from three possible genes (or their splice varisponsible for the hormone-sensitive synthesis of the ants). Class IA can be activated directly by the associalipid messenger phosphatidylinositol(3,4,5)-trisphostion of the SH2 domains of their regulatory subunits phate. Type IA and I...